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Treatment
  • The treatment of melasma remains a challenge. Numerous treatment options, including topical agents, chemical peels and laser treatments have been tried for treating melasma. The triple fixed combination cream containing hydroquinone, retinoic acid and steroid for a duration of 8 weeks is generally recommended to treat melasma with a superior efficacy than hydroquinone monotherapy 1.

  • Intense pulsed light has shown some efficacy in the treatment of melasma but the risk of PIH (Post Inflammatory Hyperpigmentation) still remains high 2.

  • Fractional laser treatments have been reported to improve melasma. However, a recent report showed that the therapeutic efficacy of fractional lasers did not differ from that of conventional therapies 3.
  1. Kang HY, Valerio L, Bahadoran P, Ortonne JP. The role of topical retinoids in the treatment of pigmentary disorders: an evidence-based review. Am J Clin Dermatol. 2009;10:251-260. [PubMed]

  2. Negishi K, Kushikata N, Tezuka Y, Takeuchi K, Miyamoto E, Wakamatsu S. Study of the incidence and nature of "very subtle epidermal melasma" in relation to intense pulsed light treatment. Dermatol Surg. 2004;30:881-886. [PubMed]

  3. Lee HS, Won CH, Lee DH, An JS, Chang HW, Lee JH, et al. Treatment of melasma in Asian skin using a fractional 1,550-nm laser: an open clinical study. Dermatol Surg. 2009;35:1499-1504. [PubMed]