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Product Prescribing Info

Hydroquinone, Tretinoin and Mometasone Furoate Cream

COMPOSITION
Hydroquinone USP 2% W/W
Tretinoin USP 0.025% W/W
Mometasone Furoate IP 0.1% W/W
PHARMACOLOGY
  • Hydroquinone is classified therapeutically as a depigmenting agent.
  • Tretinoin is all- trans – retinoic acid formed from the oxidation of the aldehyde group of retinene to a carboxyl group.
  • Tretinoin is classified as a keratolytic agent.
  • Mometasone furoate is a synthetic corticosteroid with anti-inflammatory activity.
  • The combination agents in MELACARE act by inhibiting one or more steps in the tyrosine-tyrosinase pathway of melanin synthesis. It also affects the formation of melanization and degradation of melanosomes and eventually causes necrosis of the whole melanocytes. The hyperpigmented areas fade rapidly than surrounding normal skin; 80% of patients with melasma may note some improvement within 8 week period.
INDICATIONS Melacare Cream is indicated for gradual bleaching of hyper pigmentation skin condition such as cholasma, melasma, freckles. senile lentigines and other unwanted areas of melanin hyper pigmentation. CONTRAINDICATIONS
  • Prior history of allergic reaction to Hydroquinone, Tretinoin and Mometasone.
  • The safety of Melacare during pregnancy and children (12 years and under) has not been established.
  • Caution to be exercised when Melacare is administered to nursing woman.
PRECAUTIONS
  • Strictly for external use only.
  • Important to avoid contact with eye and mucous membranes. Exposure to sunlight or UV light will cause regimentation of bleached area.
ADVERSE REACTIONS
The adverse reactions reported are Dryness, fissuring of paranasal and infraorbital areas, erythema and stinging. Occasional hypersensitivity ( localized contact dermatitis) may develop. If this occurs, medication should be discontinued and physician must be notified immediately. DIRECTION FOR USE
Melacare should be applied preferably once daily in the evening. Duration of application must be decided by the physician depending upon the response given by the patient.
STORAGE
  • Store below 25° C.
  • Protect from light. Do not freeze.
  • Keep tube tightly closed after use.
  • Keep out of the reach of children.
PRESENTATION
20g Cream available in laminated tube.